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Andexanet alfa

A Pharmacology term on the RCIS & RCES exam blueprint, defined for cath lab and EP clinicians.

A decoy-receptor reversal agent for Factor Xa inhibitors (apixaban, rivaroxaban), withdrawn from the US market in December 2025 after reports of thromboembolic events, including fatal ones. Still sold in some other countries. In the US, 4F-PCC is now used for life-threatening bleeding on these drugs.

Domain: Pharmacology · Blueprint: RCIS & RCES exam guide

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Written and reviewed by John-Philip (JP) Maarschalk, RN, BSN, CNML — a nurse manager who runs operations for the cardiac cath lab, electrophysiology, and interventional service lines at an academic health system in North Carolina. He hires and develops the staff who sit for these exams. More about JP and how this content is made →
Cardiac Codex is an independent study tool published by MdoubleA LLC, not affiliated with or endorsed by CCI or any certifying body. This glossary entry is exam-preparation information, not medical advice or a substitute for clinical judgment. Always verify current clinical practice against primary sources and institutional protocol.